Loss of protein synthesis quality control in intracellular organisms

Our recent work provides a compelling evidence that intracellular parasitism is a lifestyle which eradicates one of the most fundamental properties of a living cell – its ability to accurately translate the genetic code into a protein sequence.

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Protein synthesis in parasites with tiniest genomes is accompanied with remarkable number of errors

The project's most recent paper suggests that Microsporidia – parasites that have the smallest genome among eukaryotes, – have an error-prone protein synthesis machinery and make random errors during protein synthesis that greatly diversify proteomes of these pathogenic species:

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