Side-by-side comparison of protein uS7 from major taxonomic groups of organisms. Labels point to protein segments that are found only in a subset of species. 

                         Side-by-side comparison of protein uS7 from major taxonomic groups of organisms. Labels point to protein segments that are found only in a subset of species. 


 

us7

uS7 is a protein that forms part of the messenger RNA channel of the ribosome: uS7 has a long β-hairpin that reaches the messenger RNA in the ribosomal E site. Notably, this uS7 hairpin has different structure in bacteria compared to eukaryotes, although it is unclear whether this structural differences influence the process of protein synthesis.

uS7 is one of a few ribosomal proteins that is longer in single-cell fungi, such as yeasts, as compared to higher eukaryotes, such as humans: in fungi, uS12 has an additional N-terminal extension that is required for high fidelity of protein synthesis in yeasts [1]. 

uS7 is especially distinct in mitochondria (as compared to its homologs in bacteria, archaea and eukaryotes).